Oligonucleotides Containing Acyclic Nucleoside Analogues with Carbamate Internucleoside Linkages |
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Authors: | Ivan Habus Sudhir Agrawal |
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Institution: | Hybridon Inc., One Innovation Drive , Worcester, MA 01605, U.S.A. |
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Abstract: | Abstract Synthesis of 2′-deoxy-2′,3′-secothymidine t and its dimer t?t, where the two 2′-deoxy-2′,3′-secothymidine t units are connected via a carbamate, ?=3′-NH-CO-O-5′, internucleoside linkage has been achieved. These building blocks were protected in the 5′-position, converted into their phosphoramidites, or attached onto CPG, and then used for “chimeric oligonucleotide” synthesis. |
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