Synthesis of Novel Pyrene-Bearing C-Nucleoside and Its Incorporation into Oligonucleotides |
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| Authors: | Natalia Dyatkina Alexander Khorlin Yuri Khrlin Kyoichi A Watanabe |
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| Institution: | CODON Pharmaceuticals, Inc. , 200 Perry Parkway., Gaithersburg, Maryland, 20877, USA |
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| Abstract: | Abstract Phosphoramidite of (1,2,4-triazol-1-yl)-4-(4-pyren-1-ylbutyl)amino]-5-(2-O-methyl-5-dimethoxytrityl-β-D-ribofuranosyl)pyrimidine has been synthesized, incorporated into polypyrimidine oligoaucleotides, and studied for thier triplex forming capacity. |
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