Stereoselective synthesis of conformationally rigid apio carbanucleosides as potential antiviral agents |
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Authors: | Moon Hyung Ryong Kim Kyung Ran Kim Bum Tae Hwang Ki Jun Chun Moon Woo Jeong Lak Shin |
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Institution: | College of Pharmacy, Pusan National University, Pusan 609-735, Korea. |
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Abstract: | Apio north-methanocarbocyclic nucleosides 1-3 with bicyclo3. 1.0]hexane template were first synthesized. Introduction of hydroxymethyl substituent was efficiently and stereoselectively accomplished by aldol and retro-aldol reaction and fixed conformation was achieved from a modified Simmons-Smith cyclopropanation on a cyclopentane ring. |
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