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A Novel and Convenient Method for the Synthesis of Free 5′-Thiol Modified Oligonucleotides |
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| Abstract: | Abstract The synthesis of free 5′-thiol-modified oligonucleotides using a 4,4′,4″-trimethoxytrityl (TMTr)-protected linker and standard Poly-PakTM purification has been described. |
| Keywords: | 5′-Thiol linker TMTr removal Oligonucleotide conjugation Phosphoramidite |