Characterization of a Small Family (CAIII) of Microsatellite-Containing Sequences with X-Y Homology |
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| Authors: | Patrizia Malaspina Bianca Maria Ciminelli Luigi Viggiano Carla Jodice Fulvio Cruciani Piero Santolamazza Daniele Sellitto Rosaria Scozzari Luciano Terrenato Mariano Rocchi Andrea Novelletto |
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| Institution: | (1) Department of Biology, University ``Tor Vergata', Via della Ricerca Scientifica, 00133 Rome, Italy, IT;(2) Consorzio C.A.R.S.O., 70126 Bari, Italy, IT;(3) Department of Genetics and Molecular Biology, University ``La Sapienza', 00185 Rome, Italy, IT;(4) Institute of Genetics, University of Bari, 70126 Bari, Italy, IT |
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| Abstract: | Four X-linked loci showing homology with a previously described Y-linked polymorphic locus (DYS413) were identified and characterized.
By fluorescent in situ hybridization (FISH), somatic cell hybrids, and YAC screening, the X-linked members of this small family
of sequences (CAIII) all map in Xp22, while the Y members map in Yq11. These loci contribute to the overall similarity of
the two genomic regions. All of the CAIII loci contain an internal microsatellite of the (CA)n type. The microsatellites display extensive length polymorphism in two of the X-linked members as well as in the Y members.
In addition, common sequence variants are found in the portions flanking the microsatellites in two of the X-linked members.
Our results indicate that, during the evolution of this family, length variation on the Y chromosome was accumulated at a
rate not slower than that on the X chromosome. Finally, these sequences represent a model system with which to analyze human
populations for similar X- and Y-linked polymorphisms.
Received: 29 July 1996 / Accepted: 15 January 1997 |
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| Keywords: | : Human Y chromosome — Y polymorphisms — X-Y homology — Microsatellites |
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