首页 | 本学科首页   官方微博 | 高级检索  
   检索      


On the rate of DNA sequence evolution inDrosophila
Authors:Paul M Sharp  Wen-Hsiung Li
Institution:(1) Department of Genetics, Trinity College, 2 Dublin, Ireland;(2) Center for Demographic and Population Genetics, University of Texas, PO Box 20334, 77225 Houston, Texas, USA
Abstract:Summary Analysis of the rate of nucleotide substitution at silent sites inDrosophila genes reveals three main points. First, the silent rate varies (by a factor of two) among nuclear genes; it is inversely related to the degree of codon usage bias, and so selection among synonymous codons appears to constrain the rate of silent substitution in some genes. Second, mitochondrial genes may have evolved only as fast as nuclear genes with weak codon usage bias (and two times faster than nuclear genes with high codon usage bias); this is quite different from the situation in mammals where mitochondrial genes evolve approximately 5–10 times faster than nuclear genes. Third, the absolute rate of substitution at silent sites in nuclear genes inDrosophila is about three times hihger than the average silent rate in mammals.
Keywords:Drosophila            Molecular clock  mtDNA  Nuclear DNA  Silent substitutions  Codon usage bias  Divergence time
本文献已被 SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号