Identification of Glyoxalase I Sequences in Brassica oleracea and Sporobolus stapfianus: Evidence for Gene Duplication Events |
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Authors: | Susan L Clugston Elisabeth Daub John F Honek |
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Institution: | (1) Department of Chemistry, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1, CA |
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Abstract: | Glyoxalase I (GlxI) is the first of two enzymes involved in the cellular detoxification of methylglyoxal. A recent search
of the National Center for Biotechnology Information (NCBI) databases with the protein sequence of Salmonella typhimurium GlxI identified two new hypothetical proteins with unassigned function. These two sequences, from Brassica oleracea and Sporobolus stapfianus, have significant sequence similarity to known GlxI sequences, suggesting that these two open reading frames encode for GlxI
in these plants. Interestingly, analysis of these two new sequences indicates that they code for a protein composed of two
fused monomers, a situation previously found solely in the yeast GlxI enzymes.
Received: 10 May 1997 / Accepted: 15 October 1997 |
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Keywords: | :S-d-Lactoylglutathione methylglyoxal lyase — Gene duplication — Sequence comparison |
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