Phylogenetic Analysis of Invertebrate Lysozymes and the Evolution of Lysozyme Function |
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Authors: | Sana Bachali Muriel Jager Alexandre Hassanin Françoise Schoentgen Pierre Jollès Aline Fiala-Medioni Jean S Deutsch |
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Institution: | (1) UMR 7622, ``Biologie du Développement,' CNRS et Université P. et M. Curie, Paris, France, FR;(2) Service de Biosystématique, Université P. et M. Curie, Paris, France, FR;(3) Centre de Biophysique Moléculaire, CNRS, Orléans, France, FR;(4) Laboratoire de Chimie du Muséum National d'Histoire Naturelle, Paris, et LMCP, Université P. et M. Curie, Paris, France, FR;(5) Observatoire de Banyuls, Université P. et M. Curie, Paris, France, FR |
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Abstract: | We isolated and sequenced the cDNAs coding for lysozymes of six bivalve species. Alignment and phylogenetic analysis showed
that, together with recently described bivalve lysozymes, the leech destabilase, and a number of putative proteins from extensive
genomic and cDNA analyses, they belong to the invertebrate type of lysozymes (i type), first described by Jollès and Jollès
(1975). We determined the genomic structure of the gene encoding the lysozyme of Mytilus edulis, the common mussel. We provide evidence that the central exon of this gene is homologous to the second exon of the chicken
lysozyme gene, belonging to the c type. We propose that the origin of this domain can be traced back in evolution to the origin
of bilaterian animals. Phylogenetic analysis suggests that i-type proteins form a monophyletic family.
Received: 21 May 2001 / Accepted: 22 October 2001 |
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Keywords: | : Lysozyme — Destabilase — Exon shuffling — Phylogeny — Bivalves — Invertebrates |
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