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Phylogenetic Analysis of Invertebrate Lysozymes and the Evolution of Lysozyme Function
Authors:Sana  Bachali  Muriel  Jager  Alexandre  Hassanin  Françoise  Schoentgen  Pierre  Jollès  Aline  Fiala-Medioni  Jean S  Deutsch
Institution:(1) UMR 7622, ``Biologie du Développement,' CNRS et Université P. et M. Curie, Paris, France, FR;(2) Service de Biosystématique, Université P. et M. Curie, Paris, France, FR;(3) Centre de Biophysique Moléculaire, CNRS, Orléans, France, FR;(4) Laboratoire de Chimie du Muséum National d'Histoire Naturelle, Paris, et LMCP, Université P. et M. Curie, Paris, France, FR;(5) Observatoire de Banyuls, Université P. et M. Curie, Paris, France, FR
Abstract:We isolated and sequenced the cDNAs coding for lysozymes of six bivalve species. Alignment and phylogenetic analysis showed that, together with recently described bivalve lysozymes, the leech destabilase, and a number of putative proteins from extensive genomic and cDNA analyses, they belong to the invertebrate type of lysozymes (i type), first described by Jollès and Jollès (1975). We determined the genomic structure of the gene encoding the lysozyme of Mytilus edulis, the common mussel. We provide evidence that the central exon of this gene is homologous to the second exon of the chicken lysozyme gene, belonging to the c type. We propose that the origin of this domain can be traced back in evolution to the origin of bilaterian animals. Phylogenetic analysis suggests that i-type proteins form a monophyletic family. Received: 21 May 2001 / Accepted: 22 October 2001
Keywords:: Lysozyme —  Destabilase —  Exon shuffling —  Phylogeny —  Bivalves —  Invertebrates
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