Modulation of Base-Specific Mutation and Recombination Rates EnablesFunctional Adaptation Within the Context of the Genetic Code |
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Authors: | Taison Tan Leonard D Bogarad Michael W Deem |
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Institution: | (1) Department of Bioengineering and Department of Physics & Astronomy, Rice University, 6100 Main Street—MS 142, Houston, TX 77005-1892, USA;(2) Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA |
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Abstract: | The persistence of life requires populations to adapt at a rate commensurate with the dynamics of their environment. Successful populations that inhabit highly variable environments have evolved mechanisms to increase the likelihood of successful adaptation. We introduce a 64 × 64 matrix to quantify base-specific mutation potential, analyzing four different replicative systems, error-prone PCR, mouse antibodies, a nematode, and Drosophila. Mutational tendencies are correlated with the structural evolution of proteins. In systems under strong selective pressure, mutational biases are shown to favor the adaptive search of space, either by base mutation or by recombination. Such adaptability is discussed within the context of the genetic code at the levels of replication and codon usage.Supplementary material to this paper is available in electronic form.Reviewing Editor: Dr. Edward Trifonov |
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Keywords: | Codon usage Codon mutation matrix Mutation rate Recombination rate |
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