The predictive value of the first-trimester maternal serum chemerin level for pre-eclampsia |
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| Institution: | 1. Department of Animal Sciences, Colorado State University, Fort Collins, CO 80523, USA;2. Animal Reproduction and Biotechnology Laboratory, Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA;3. Division of Animal Sciences, University of Missouri, Columbia, MO 65211, USA;1. School of Medicine, University of Adelaide, Australia;2. NHMRC Centre of Research Excellence in Translating Nutritional Sciences to Good Health, Adelaide, Australia;1. Division de Physiopathologie clinique, Centre hospitalier universitaire vaudois and University of Lausanne, Switzerland;2. Département de Gynécologie-obstétrique, Centre hospitalier universitaire vaudois and University of Lausanne, Switzerland;3. Laboratoire central de Chimie clinique, Centre hospitalier universitaire vaudois and University of Lausanne, Switzerland;4. Service de Médecine intensive adulte, Centre hospitalier universitaire vaudois and University of Lausanne, Switzerland;1. Department of Ultrasound, Fudan University Affiliated Huashan Hospital Jing''An Branch, Shanghai, China;2. Department of Neurosurgery, Fudan University Affiliated Huashan Hospital, Shanghai, China;1. International University of Health and Welfare Mita Hospital, Tokyo, Japan;2. Department of Cardiovascular Medicine, Toho University Medical Center, Tokyo, Japan;3. Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;4. Integrative Stroke Imaging Center, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan;6. National Cerebral and Cardiovascular Center Hospital, Suita, Osaka, Japan;5. Department of Neurosurgery, Kyoto University, Kyoto, Japan;7. Department of Medical Affairs, Bayer Yakuhin, Ltd, Osaka, Japan |
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| Abstract: | Chemerin is a novel adipokine linked to inflammation. The cross-sectional studies have reported that maternal chemerin serum concentrations are significantly increased in pre-eclampsia. However, limited data are available regarding the cause-effect relationship between chemerin and pre-eclampsia. The aim of this prospective observational study was to evaluate predictive significance of the first-trimester maternal serum chemerin levels for pre-eclampsia and to further confirm the hypothesis that chemerin is an important causative factor in the pathogenesis of pre-eclampsia. 518 pregnancy women were recruited. The first-trimester maternal serum chemerin levels were determined using enzyme-linked immunosorbent assay. The first-trimester maternal serum chemerin levels were statistically significantly elevated in women with pre-eclampsia compared with those without pre-eclampsia and in severe pre-eclampsia women compared with mild pre-eclampsia women. Serum chemerin levels remained positively associated with plasma C-reactive protein levels using a linear regression model. A logistic-regression analysis demonstrated that body mass index and serum chemerin levels appeared to be the independent predictors of pre-eclampsia. A receiver–operating characteristic curve analysis identified that serum chemerin levels predicted pre-eclampsia with high predictive value. The predictive value of the chemerin concentrations was similar to that of body mass index. Chemerin improved the predictive value of body mass index statistically significantly. Thus, our results suggest that high serum chemerin levels are associated with inflammation and pre-eclampsia independently, as well as chemerin may play a role as predictive biomarker for pre-eclampsia and be an important causative factor in the pathogenesis of pre-eclampsia. |
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| Keywords: | Chemerin Pre-eclampsia Predictor Biomarker Pathogenesis |
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