Enhanced levels of immunoreactive β-casomorphin-8 in milk of breastfeeding women with mastitis |
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| Institution: | 1. Department of Paediatrics, University Hospital, Malmö, University of Lund, Lund, Sweden;2. Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden;1. Cambridge Breast Unit, Cambridge University Hospitals NHS Foundation Trust, NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0QQ, UK;2. Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK;1. Department of Food Physics and Meat Science, Institute of Food Science and Biotechnology, University of Hohenheim, Garbenstraße 21/25, 70599 Stuttgart, Germany;2. Department of Dairy Science and Technology, Institute of Food Science and Biotechnology, University of Hohenheim, Garbenstraße 25, 70599 Stuttgart, Germany;3. Institut für Physikalische Chemie, Universität Stuttgart, Pfaffenwaldring 55, 70569 Stuttgart, Germany;1. Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham & Women’s Hospital, Boston, MA, USA;2. Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden;3. Neurobiology Department, Children’s Hospital Boston, Harvard Medical School, Boston, MA, USA;4. Harvard School of Dental Medicine, Boston, MA, USA;5. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA |
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| Abstract: | An incorrect, superficial suckling technique in breastfeeding frequently leads to milk congestion and sometimes mastitis. In the present study we have examined whether milk congestion may affect levels of the atypical opioid β-casomorphin-8 in milk and in plasma. We also investigated whether the rate of acute psychosis during the first half year after parturition has declined in Sweden over the years. Milk and plasma samples were collected for peptide analysis from 14 women with mastitis and 10 controls. We found that in a group of 14 late cases of mastitis (median 48 days post partum) the detected mean level of β-casomorphin-8 in milk was significantly higher and somewhat higher in plasma at the acute stage compared with 2–3 weeks later, after recovery when the symptoms had disappeared, as well as compared to the control subjects. Swedish official statistics show that the incidence of acute psychosis in the first month and in the first half year after birth has declined by a half during the last 30 years. A relationship between postpartum psychosis and elevated β-casomorphin-8 levels in CSF has been suggested from earlier studies. In this study, milk congestion led to enhanced levels of β-casomorphin-8 in milk, which may be related to postpartum psychosis and probably also to ‘the postnatal blues’. |
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| Keywords: | Atypical opioids β-Casomorphins Lactation Radioimmunoassay Mastitis Postpartum psychosis |
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