Ghrelin receptors in human gastrointestinal tract during prenatal and early postnatal development |
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| Institution: | 1. Institute for Medical Research, University of Belgrade, Serbia;2. Institute for Nature Conservation of Serbia, Belgrade, Serbia;1. Department of Physiology, Instituto Nacional de Cardiología “Ignacio Chávez”, Mexico D.F., Mexico;2. Department of Pharmacology, Instituto Nacional de Cardiología ``Ignacio Chávez'''' Mexico D.F., Mexico;3. Department of Molecular Biology, Instituto Nacional de Cardiología ``Ignacio Chávez'''' Mexico D.F., Mexico;4. Department of Reproductive Biology, Instituto Nacional de Ciencias Médicas y de la Nutrición “Salvador Zubirán”, Mexico D.F., Mexico;1. Department of Vascular Surgery, Medical School, University of Athens, Greece;2. First Department of Internal Medicine, “Hippokratio” General Hospital of Thessaloniki, Greece;1. Department of Comparative Biomedicine and Food Science, University of Padova, Viale dell''Università 16, 35020 Legnaro, PD, Italy;2. Department of Veterinary Medical Sciences, Alma Mater Studiorum, University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano Emilia, BO, Italy;3. Department for Innovation in Biological, Agro-food and Forest Systems, Tuscia University, Via San Camillo de Lellis s.n.c., 01100 Viterbo, Italy;1. Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea;2. Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea;1. School of Architecture and Civil Engineering, Northeast Petroleum University, Fazhan Lu Street, Daqing 163318, China;2. College of Engineering, Mechanical Engineering Department, Babylon City, Hilla, Iraq |
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| Abstract: | The aim of our study was to investigate the appearance, density and distribution of ghrelin cells and GHS-R1a and GHS-R1b in the human stomach and duodenum during prenatal and early postnatal development. We examined chromogranin-A and ghrelin cells in duodenum, and GHS-R1a and GHS-R1b expression in stomach and duodenum by immunohistochemistry in embryos, fetuses, and infants. Chromogranin-A and ghrelin cells were identified in the duodenum at weeks 10 and 11 of gestation. Ghrelin cells were detected individually or clustered within the base of duodenal crypts and villi during the first trimester, while they were presented separately within the basal and apical parts of crypts and villi during the second and third trimesters. Ghrelin cells were the most numerous during the first (～11%) and third (～10%) trimesters of gestation development. GHS-R1a and GHS-R1b were detected at 11 and 16 weeks of gestation, showed the highest level of expression in Brunner's gland and in lower parts of duodenal crypts and villi during the second trimester in antrum, and during the third trimester in corpus and duodenum. Our findings demonstrated for the first time abundant duodenal expression of ghrelin cells and ghrelin receptors during human prenatal development indicating a role of ghrelin in the regulation of growth and differentiation of human gastrointestinal tract. |
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| Keywords: | Human fetal duodenum GHS-R1a and GHS-R1b Appearance Distribution and density of ghrelin cells |
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