Nesfatin-1 – More than a food intake regulatory peptide |
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| Institution: | 1. Department of Animal Physiology and Biochemistry, Poznań University of Life Sciences, 60-637 Poznań, Poland;2. Institute of Zoology, Poznań University of Life Sciences, 60-637 Poznań, Poland;3. Department of Hepatology and Gastroenterology, Interdisciplinary Centre of Metabolism: Endocrinology, Diabetes and Metabolism, Charité-University Medicine Berlin, 13353 Berlin, Germany;4. Department of Internal Medicine-Gastroenterology, Park-Klinik Weissensee, 13086 Berlin, Germany;1. The Key Laboratory of Reproductive Genetics, Ministry of Education (Zhejiang University), Hangzhou, China;2. The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China;3. Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Hangzhou, China;4. Department of Reproductive Endocrinology, Women''s Hospital, Zhejiang University, Hangzhou, China;5. Department of Obstetrics and Gynecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada |
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| Abstract: | Nesfatin-1 was discovered a decade ago and despite the fact that it represents just one of a multitude of food intake-inhibiting factors it received increasing attention. This led to a detailed characterization of NUCB2/nesfatin-1's physiological property to reduce food intake and also gave rise to an involvement in the long term regulation of body weight, especially under conditions of obesity. In addition, studies indicated the involvement of NUCB2/nesfatin-1 in other homeostatic functions as well: glucose homeostasis, water intake, gastrointestinal functions, temperature regulation, cardiovascular functions, puberty onset and sleep. These pleiotropic actions underline the physiological relevance of this peptide. Recently, the involvement of NUCB2/nesfatin-1 in psychiatric disorders such as anxiety has been investigated giving rise to the speculation that NUCB2/nesfatin-1 represents a peptidergic link between eating and anxiety/depression disorders. |
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| Keywords: | Anxiety Brain-gut Hypothalamus NUCB2 Nucleobindin2 Stomach |
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