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The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance
Authors:Nicola Vannini  Vasco Campos  Mukul Girotra  Vincent Trachsel  Shanti Rojas-Sutterlin  Josefine Tratwal  Simone Ragusa  Evangelos Stefanidis  Dongryeol Ryu  Pernille Y Rainer  Gena Nikitin  Sonja Giger  Terytty Y Li  Aikaterini Semilietof  Aurelien Oggier  Yannick Yersin  Loïc Tauzin  Eija Pirinen  Olaia Naveiras
Institution:1. Laboratory of Regenerative Hematopoiesis, Swiss Institute for Experimental Cancer Research (ISREC) & Institute of Bioengineering (IBI), School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland;2. Department of Oncology UNIL CHUV, Ludwig Institute for Cancer Research Lausanne, University of Lausanne, Epalinges 1066, Switzerland;3. Laboratory of Stem Cell Bioengineering, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland;4. Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupolis, Greece;5. Laboratory of Integrative and Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland;6. Laboratory of System Biology and Genetics, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland;7. Flow Cytometry Platform, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland;8. Nestlé Research, EPFL Innovation Park, 1015 Lausanne, Switzerland;9. School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland;10. Department of Obstetrics, University Hospital Zürich, University of Zürich, Zürich, Switzerland;11. Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences. Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland;12. Service and Central Laboratory of Hematology, Departments of Oncology and of Laboratories, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland;13. Service d’orthopédie et de traumatologie, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland;14. Institute of Chemical Sciences and Engineering, School of Basic Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
Abstract:
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  • Keywords:hematopoietic stem cell  HSC  long-term hematopoietic stem cell  mitochondria  mitochondrial clearance  mitochondrial recycling  autophagy  mitophagy  mitonuclear protein imbalance  unfolded protein response mitochondria  UPRmt  asymmetric stem cell division  hematopoietic stem cell transplantation  bone marrow transplantation  bone marrow failure  bone marrow aplasia  human CD34+ progenitors  immune thrombocytopenia  aplastic anemia  chemotherapy  radiotherapy  myelodysplasia  myelodysplastic syndrome
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