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Single-cell analysis of the developing human testis reveals somatic niche cell specification and fetal germline stem cell establishment
Authors:Jingtao Guo  Enrique Sosa  Tsotne Chitiashvili  Xichen Nie  Ernesto Javier Rojas  Elizabeth Oliver  Kathrin Plath  James M Hotaling  Jan-Bernd Stukenborg  Amander T Clark  Bradley R Cairns
Institution:1. Howard Hughes Medical Institute, Department of Oncological Sciences and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT 84112, USA;2. Division of Urology, Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT 84112, USA;3. Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA;4. Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA;5. NORDFERTIL Research Laboratory Stockholm, Childhood Cancer Research Unit, Bioclinicum J9:30, Department of Women’s and Children’s Health, Karolinska Institutet and Karolinska University Hospital, Solna 17164, Sweden;6. DonorConnect, Murray, UT 84107, USA
Abstract:
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  • Keywords:single-cell RNA sequencing  fetal testis development  primordial germ cell  spermatogonial stem cell  Sertoli cell  Leydig cell  interstitial cell
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