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Whole-genome analysis of human embryonic stem cells enables rational line selection based on genetic variation
Institution:1. Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA;2. Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA;3. Harvard Stem Cell Institute, Cambridge, MA 02138, USA;4. Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;5. Wellcome – MRC Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK;6. Wellcome – MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK;7. Department of Genetics, Harvard Medical School, Boston, MA 02115, USA;8. Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;9. Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA;10. Department of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ 08901, USA;11. Department of Psychiatry, New Jersey Medical School, Rutgers University, Newark, NJ 07103, USA;12. Centre for Population Genomics, Garvan Institute of Medical Research, and UNSW Sydney, Sydney, NSW, Australia;13. Centre for Population Genomics, Murdoch Children’s Research Institute, Melbourne, VIC, Australia
Abstract:
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  • Keywords:pluripotent  embryonic stem cell  whole-genome sequencing  genomics  genetic variant  resource  rational selection
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