Canine lymphoma-associated antigens defined by murine monoclonal antibodies |
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| Authors: | Zenon Steplewski K Ann Jeglum Carlos Rosales Nancy Weintraub |
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| Institution: | (1) The Wistar Institute, 36th at Spruce, 19104 Philadelphia, PA, USA;(2) School of Veterinary Medicine, University of Pennsylvania, 38th at Spruce, 19104 Philadelphia, PA, USA |
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| Abstract: | Summary Lymphoma in dogs resembles human non-Hodgkin's lymphoma in pathological presentation, immunophenotype, and response to therapy, thus representing a good model for comparative studies with human disease. Monoclonal antibodies (MAbs) were derived from mice immunized with a dog lymphoma cell line. Three MAbs were selected for further application in immunophenotyping and immunotherapy. The binding specificities, antigen characterization, and isotypes for these MAbs are described.Supported by NCI grant CA-10815 |
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