Administration of embryonic stem cells generates effective antitumor immunity in mice with minor and heavy tumor load |
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Authors: | Wei Dong Jiajun Du Hongchang Shen Dongwei Gao Zhenxiang Li Guanghui Wang Xueru Mu Qi Liu |
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Institution: | (1) Department of Oncology, Shandong Provincial Hospital, Shandong University, 324 Jingwu Road, Jinan, 250012, P. R. China;(2) Department of Thoracic Surgery, Shandong Provincial Hospital, Shandong University, 324 Jingwu Road, Jinan, 250012, P. R. China; |
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Abstract: | The history of immunizing animals with fetal tissues to generate an antitumor response dates back a century ago. Subsequent
reports supported the idea that vaccination with embryonic materials could generate cancer-specific immunity and protect animals
from transplantable and chemically induced tumors. In our study, we found C57 BL/6 mice vaccinated with embryonic stem cells
(ESCs) received obvious antitumor immunity, which protected them from the formation and development of lung cancer. Furthermore,
we investigated the antitumor effects of administration of ESCs in mice with minor and/or heavy tumor load. The tumor growth
was monitored, the proliferation of lymphocytes and secretion of cytokines were examined, and finally the tissue sections
were approached by immunohistochemical and apoptosis staining. The results suggested that mice injected with ESCs received
obvious tumor inhibition and retardation due to significant lymphocyte proliferation and cytokine secretion, which help to
rebuild the host’s immunity against cancer to some extent and comprise the main part of antitumor immunity. Moreover, mice
with minor tumor load received stronger antitumor effect compared with mice with heavy tumor load, may be due to relatively
intact immune system. Thus, besides their function as prophylactic vaccines, administration of ESCs could be a potential treatment
for cancer, which obviously prevent and control the proliferation and development of malignant tumors. |
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