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Enhanced K-cell activity in the peripheral blood of patients with malignant disease |
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| Authors: | Tibor Bakács Pál Czanik Ian Kimber Gábor Ringwald Michael Moore and Erzsébet Ábrahám |
| Institution: | (1) National Institute of Oncology, Ráth Gy. u. 7-9, Budapest XII., Hungary;(2) Bajcsy-Zsilinszky Hospital, Köbányai ut 45, Budapest X., Hungary;(3) Department of Immunology, Paterson Laboratories, Christie Hospital and Holt Radium Institute, M20 9BX Manchester, U.K. |
| Abstract: | Summary We have analysed the influence of human malignant, inflammatory and infectious disease on the capacity of peripheral lymphocytes to mediate antibody-dependent haemolysis. The application of an enzyme-like kinetic model for measurement of maximal cytotoxic function has permitted reproducible and sensitive determinations of the K-cell function. The results show that malignant disease is associated with enhancement of ADCC capacity. |
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