Heat shock proteins: biological functions and clinical application as personalized vaccines for human cancer |
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| Authors: | Chiara?Castelli Licia?Rivoltini Francesca?Rini Filiberto?Belli Alessandro?Testori Michele?Maio Vincenzo?Mazzaferro Jorgelina?Coppa Pramod?K?Srivastava Email author" target="_blank">Giorgio?ParmianiEmail author |
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| Institution: | (1) Unit of Immunotherapy of Human Tumors, Istituto Nazionale per lo Studio e la Cura dei Tumori, Via G. Venezian 1, 20133 Milan, Italy;(2) Unit of General Surgery, Istituto Nazionale per lo Studio e la Cura dei Tumori, Via G. Venezian 1, 20133 Milan, Italy;(3) European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy;(4) Unit of Cancer Bioimmunotherapy, Department of Medical Oncology, Centro di Riferimento Oncologico, Via Pedemontana Occidentale 12, 33081 Aviano, Italy;(5) Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, Farmington, USA;(6) Unit of Hepatobiliary and Gastro-Pancreatic Surgery, Istituto Nazionale per lo Studio e la Cura dei Tumori, Via G. Venezian 1, 20133 Milan, Italy |
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| Abstract: | Heat shock proteins (HSPs) are a large family of proteins with different molecular weights and different intracellular localizations. These proteins undertake crucial functions in maintaining cell homeostasis, and therefore they have been conserved during evolution. Hsp70 and Grp94/gp96, due to their peptide chaperone capacity and their ability to actively interact with professional antigen-presenting cells (APCs), are also endowed with crucial immunological functions. The immunological properties of these proteins and their implications for vaccine in human cancer will be discussed. Immunological and clinical data of phase I/II studies in melanoma and colorectal cancer patients will be reviewed.This work was presented at the first Cancer Immunology and Immunotherapy Summer School, 8–13 September 2003, Ionian Village, Bartholomeio, Peloponnese, Greece. |
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| Keywords: | Heat shock proteins Cross-priming Vaccination Melanoma Colorectal cancer Peptides |
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