Lymphocyte subpopulations of regional lymph nodes in human colon and gastric adenocarcinomas |
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Authors: | Beatriz Lores-Vazquez Margarita Pacheco-Carracedo Josefina Oliver-Morales Purificación Parada-Gonzalez F Gambón-Deza |
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Institution: | (1) Unidad de Inmunologia, Hospital do Meixoeiro, Apdo.s/n. 36200 Vigo, Spain, ES;(2) Servicio de Anatomía Patológica, Hospital do Meixoeiro, Vigo, Spain, ES;(3) Servicio de Cirugia General, Hospital do Meixoeiro, Vigo, Spain, ES |
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Abstract: | In order to study the host immune response to tumours, previous knowledge of the cellular composition of regional draining
lymph nodes is necessary. Enlarged regional lymph nodes are a common finding in colon and gastric adenocarcinomas. We have
studied the cellular composition of normal non-reactive and of regional draining lymph nodes of colon and gastric adenocarcinomas.
In normal non-reactive lymph nodes, T lymphocytes (CD2+, CD7+) constituted the largest fraction of the lymphoreticular cells. These lymphocytes were mainly CD4+, and there were more cells expressing the CD45RA isoform of the CD45 antigen than CD45RO. Reactive lymph nodes presented
a decreased proportion of CD4+ CD45RA+ cells and an increased number of B cells. Although most of the T cells in the reactive nodes were CD4+ CD45RO+, their proportion was similar to that found in normal non-reactive nodes. We studied the presence of the molecules CD28 and
CD80 involved in the processes of interaction and activation of T and B lymphocytes. The CD28 molecule was found in all the
T lymphocytes, while the CD80 molecule was weakly expressed on the B lymphocyte membrane.
Received: 4 January 1996 / Accepted: 28 May 1996 |
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Keywords: | Lymph node T Lymphocytes CD45 antigen Tumour immunology |
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