| 哺乳动物孤雌干细胞与孤雌生殖 |
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| 引用本文： | 方园,柴梦佳,孔庆然,刘忠华.哺乳动物孤雌干细胞与孤雌生殖[J].中国细胞生物学学报,2021(1). |
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| 作者姓名： | 方园 柴梦佳 孔庆然 刘忠华 |
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| 作者单位： | 东北农业大学生命科学学院黑龙江省动物细胞与遗传工程重点实验室;温州医科大学检验医学与生命科学学院检验医学教育部重点实验室 |
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| 基金项目： | 国家重点研发计划“干细胞及转化研究”项目(批准号:2016YFA0100200);国家自然科学基金面上项目(批准号:31872360)资助的课题。 |
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| 摘 要： | 未受精的孤雌胚胎衍生的孤雌胚胎干细胞(parthenogenetic embryonic stem cells,pESCs),具有与胚胎干细胞(embryonic stem cells,ESCs)相似的多向分化和自我更新能力,且具备来源广泛、获取高效及低致瘤性等优势,因此成为近年来的研究热点。该文概述了pESCs特殊的组织相容性和基因组印迹特征,综述其在孤雌生殖等方面的应用,并对其在遗传疾病及临床研究中的价值进行了展望。
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| 关 键 词： | 孤雌胚胎干细胞 组织相容性 基因组印迹 孤雌生殖 |
Parthenogenetic Stem Cells and Parthenogenesis in Mammals |
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| Authors: | FANG Yuan CHAI Mengjia KONG Qingran LIU Zhonghua |
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| Institution: | (Key Laboratory of Animal Cellular and Genetic Engineering of Heilongjiang Province,College of Life Science,Northeast Agricultural University,Harbin 150030,China;Key Laboratory of Laboratory Medicine,College of Laboratory Medicine and Life Science,Ministry of Education,Wenzhou Medical University,Wenzhou 325000,China) |
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| Abstract: | As a research hotspot in recent years,pESCs(parthenogenetic embryonic stem cells)derive from unfertilized parthenogenetic embryos.pESCs not only have the similar abilities of pluripotency and self-renewal as ESCs(embryonic stem cells),but also have the advantages of wide sources,high acquisition efficiency and low tumorigenic ability.This review described the specific characteristics of pESCs in histocompatibility and genomic imprinting,and summarized its application in parthenogenesis,and prospected its value in genetic diseases and clinical research. |
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| Keywords: | parthenogenetic stem cells histocompatibility genomic imprinting parthenogenesis |
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