The relation between the effect of a subhypnotic dose of thiopental on claw
pain threshold in rats and adrenalin,noradrenalin and dopamine levels |
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Authors: | Mehmet Aksoy Ali Ahiskalioglu Ilker Ince Mine Celik Aysenur Dostbil Ufuk Kuyrukluyildiz Durdu Altuner Nezahat Kurt Halis Suleyman |
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Institution: | 1)Department of Anesthesiology and Reanimation, Faculty of Medicine, Ataturk University, 25240, #Erzurum, Turkey;2)Department of Anesthesiology and Reanimation, Faculty of Medicine, Erzincan University, 24030, #Erzincan, Turkey;3)Department of Pharmacology, Faculty of Medicine, Erzincan University, 24030,#Erzincan, Turkey;4)Department of Biochemistry, Faculty of Medicine, Ataturk University,#25340, Erzurum, Turkey |
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Abstract: | Thiopental sodium (TPS) needs to be applied together with adrenalin in order to establish
its analgesic effect in general anesthesia. We aimed to investigate the effect of TPS on
the claw pain threshold in rats and evaluated its relationship with endogenous adrenalin
(ADR), noradrenalin (NDR), and dopamine (DOP) levels. Intact and adrenalectomized rats
were used in the experiment. Intact animals were divided into the following groups: 15
mg/kg TPS (TS), 0.3 mg/kg ADR+15 mg/kg TPS (ATS) and 0.3 mg/kg ADR alone (ADR).
Adrenalectomized animals were divided into the following groups: 15 mg/kg TPS (A-TS), 0.3
mg/kg ADR+15 mg/kg TPS (A-ATS) and 0.3 mg/kg ADR alone (A-ADR). Claw pain threshold and
blood ADR, NDR, and DOP levels were measured. The TS group’s claw pain threshold was found
low. However, the claw pain thresholds of the ATS and ADR groups increased significantly.
In the A-TS group, the pain threshold decreased compared with normal, and in the A-ATS and
A-ADR groups, the pain threshold increased. TPS reduced the blood ADR levels in intact
rats; however, no significant changes were observed in the NDR and DOP levels. #TPS
provides hyperalgesia by reducing the production of ADR in rats. The present study shows
that to achieve analgesic activity, TPS needs to be applied together with ADR. |
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Keywords: | catecholamines pain rat thiopental sodium |
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