|
|||||
|
|
Caveolin-1 polymorphisms in patients with severe obstructive sleep apnea |
|
| Authors: | Selvi Asker Mehmet Taspinar Hasan Koyun Bulent Ozbay Ahmet Arisoy |
| Institution: | 1. Department of Chest Diseases, Yuzuncu Yil University School of Medicine, Van, Turkey;2. Department of Medical Biology, Yuzuncu Yil University School of Medicine, Van, Turkey;3. Biometry and Genetic Unit, Faculty of Agriculture, Yuzuncu Yil University, Van, Turkey;4. Department of Chest Diseases, Mugla Sitki Kocman University School of Medicine, Mugla, Turkey |
| Abstract: | Objective: To investigate the associations of G14713A and T29107A polymorphic variants of Caveolin-1 with severe obstructive sleep apnea (OSA). Materials and methods: This study was performed on 86 severe OSA patients and 86 controls. Genotyping was performed to investigate the association of G14713A and T29107A polymorphisms of Caveolin-1 with severe OSA. Results: The distribution of genotypes of T29107A was significantly different between controls and OSA patients with a higher proportion of TT carriers in the OSA group. Conclusion: T29107A-specific genotype of Caveolin-1 may be linked with severe OSA pathogenesis. |
| Keywords: | G14713A genotype polymorphic variant T29107A |