Metallocenter assembly in nickel-containing enzymes |
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Authors: | Robert P Hausinger |
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Institution: | (1) Departments of Microbiology and Biochemistry, 160 Giltner Hall, Michigan State University, East Lansing, MI 48824–1101, USA, US |
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Abstract: | The five known nickel-dependent enzymes include urease, hydrogenase, carbon monoxide dehydrogenase (and CO dehydrogenase/acetyl-coenzyme
A synthase), methyl-S–coenzyme M reductase, and one class of superoxide dismutase. Consistent with their disparate functions, these Ni enzymes
have distinct metallocenter structures that vary in Ni coordination geometry, number and types of metals, and the presence
of additional components. Sophisticated cellular Ni processing systems have been devised to allow for specific and functional
incorporation of Ni into these proteins. This review highlights several themes that are common to the enzyme activation processes
and summarizes current concepts related to the enzyme-specific Ni assembly pathways.
Received, accepted: 3 April 1997 |
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Keywords: | Nickel enzymes Metal Transport Metallochaperone Metal shuttle Accessory protein |
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