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Inbred lines of mice derived from long-term growth selected lines: unique resources for mapping growth genes |
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| Authors: | Lutz Bünger Anita Laidlaw Grahame Bulfield Eugene J Eisen Juan F Medrano G Eric Bradford Franz Pirchner Ulla Renne Werner Schlote William G Hill |
| Institution: | Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JT, UK, GB Roslin Institute (Edinburgh), Roslin Midlothian, EH25 9PS, UK, GB Department of Animal Science, North Carolina State University, Raleigh, North Carolina 27695, USA, US Department of Animal Science, University of California Davis, Davis, California 95616-8521, USA, US 6029 Innsbruck, Austria, AT Forschungsbereich für Genetik und Biometrie, FBN Dummerstorf-Rostock, 18196 Dummerstorf, Germany, DE Institut für Nutztierwissenschaften, Humboldt-Universit?t zu Berlin, Lentzeallee 75, 14195 Berlin, Germany, DE |
| Abstract: | Lines of mice selected for many generations for high or low growth in several laboratories around the world have been collected, and from these, inbred lines are being developed by recurrent full-sib mating in Edinburgh. There are seven high selected lines and four low lines (each low line is from the same base population as one of the high lines), and the histories of each are summarized. Mean body weight of males at 70 days of age in the Edinburgh laboratory in the heaviest inbred line (77 g) is 4.8-fold higher than in the lightest line (16 g), and 1.9-fold higher than in the least extreme high line (41 g). Litter size, food intake, and fat content also differ substantially. These inbred extreme selected lines are a uniquely valuable resource for QTL or gene mapping, candidate gene identification, and elucidation of epistatic effects. Received: 19 February 2001 / Accepted: 3 May 2001 |
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