Assignment of the dipeptidylpeptidase IV (DPP4) gene to pig Chromosome 15q21 |
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| Authors: | Preben D Thomsen Hanne Qvist Lena Marklund Leif Andersson Hans Sjöström Ove Norén |
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| Institution: | (1) Division of Anatomy, Department of Anatomy and Physiology, The Royal Veterinary and Agricultural University, Bülowsvej 13, DK-1870 Frederiksberg C, Denmark;(2) Department of Medical Biochemistry and Genetics, Laboratory C, The Panum Institute, University of Copenhagen, Copenhagen, Denmark;(3) Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden |
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| Abstract: | A porcine 2-kb partial dipeptidylpeptidase IV (DPP4, EC 3.4.14.5) cDNA clone and a porcine 16-kb genomic fragment containing parts of the DPP4 gene were isolated, characterized, and used as probes to map the DPP4 gene to pig Chr (Chr) 15q21 by fluorescence in situ hybridization. A two-allele RFLP was revealed for the DPP4 gene. This polymorphism was utilized in a linkage test against the erythrocyte antigen G (EAG), previously assigned to Chr 15, and the microsatellite S0088, which is linked to EAG. The linkage analyses revealed significant evidence for linkage confirming the assignment of DPP4 to Chr 15. |
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