Variation in the Distribution of Trace Elements in Renal Cell Carcinoma |
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Authors: | Fernanda Bernardes Calvo Dário Santos Junior Consuelo Junqueira Rodrigues Francisco José Krug Júlio Takehiro Marumo Nestor Schor Maria Helena Bellini |
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Institution: | 1.Instituto de Pesquisas Energéticas e Nucleares,Cidade Universitária IPEN-CNEN/SP,S?o Paulo,Brazil;2.Universidade Federal de S?o Paulo—UNIFESP,S?o Paulo,Brazil;3.Departamento de Cirurgia, Faculdade de Medicina,Universidade de S?o Paulo,S?o Paulo,Brazil;4.Centro de Energia Nuclear na Agricultura–USP,Piracicaba,Brazil |
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Abstract: | The development of cancer is a complex, multistage process during which a normal cell undergoes genetic changes that result
in phenotypic alterations and in the acquisition of the ability to invade other sites. Inductively coupled plasma optical
emission spectroscopy was used to estimate the contents of Al, Ca, Cd, Cr, Cu, Fe, K, Mg, Mn, Na, P, Pb, and Zn in healthy
kidney and renal cell carcinoma (RCC), and significant differences were found for all elements. Along with the progression
of the malignant disease, a progressive decrease of Cd and K was observed. In fact, for Cd, the concentration in stage T4
was 263.9 times lower than in stage T1, and for K, the concentration in stage T4 was 1.73 times lower than in stage T1. Progressive
accumulation was detected for P, Pb, and Zn in stage T4. For P, the concentration in stage T4 was 11.1 times higher than in
stage T1; for Pb, the concentration in stage T4 was 232.7 times higher than in T1; and for Zn, the concentration in T4 was
8.452 times higher than in T1. This study highlights the marked differences in the concentrations of selected trace metals
in different malignant tumor stages. These findings indicate that some trace metals may play important roles in the pathogenesis
of RCC. |
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Keywords: | Trace elements Kidney Carcinoma RCC ICP-OES |
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