Chromium (VI) Can Activate and Impair Antioxidant Defense System |
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Authors: | Nino Asatiani Tamar Kartvelishvili Marina Abuladze Lali Asanishvili Nelly Sapojnikova |
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Institution: | (1) Department of Physics of Biological Systems, Andronikashvili Institute of Physics, 6, Tamarashvili St, 0177 Tbilisi, Georgia; |
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Abstract: | The changes in glutathione-dependent cycle enzymes and catalase activities under Cr(VI)-induced oxidative stress were investigated
in two distinct cell lines: L-41−human epithelial-like cells and HLF−fetal human diploid lung fibroblasts, which differ in
tissue origin, proliferation, and antioxidant enzymes activities. The chromium concentrations from 1 to 5 μM cause nontoxic
effects and activate antioxidant enzymes to overcome oxidative stress. In spite of some differences in the endogenous antioxidant
activities, both cell lines reveal the same range of toxic concentrations (20–30 μM). The irreversible inhibition of glutathione-dependent
antioxidant enzymes develops under toxic concentrations and serves as a marker of toxicity. The endogenous antioxidant activity
influences time-dependent expression of Cr(VI) toxicity and the dynamics of antioxidant enzymes activity under nontoxic conditions.
The cell antioxidant defense system is an important marker of the cell adaptive capacity under nontoxic and toxic conditions. |
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