Effect of copper sulfate on experimental atherosclerosis |
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| Authors: | Mariana Vlad E Bordas Rodica Tomus Doina Sava Ecaterina Farkas G Uza |
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| Institution: | (1) Institute of Public Health and Medical Research, Cluj-Napoca, Romania;(2) Departmental Policlinic II, Cluj-Napoca, Romania |
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| Abstract: | Serum copper concentration increases significantly (p<0.01) in rats with experimental atherosclerosis compared to a control group. The serum zinc, the zinc, and copper concentration
in abdominal aorta and in liver decreases significantly (p<0.05) compared to the control group. Administration of copper sulfate for 100 d in these animals induces a significant increase
of serum copper (p<0.01), decrease of serum cholesterol (p<0.05) and increase of liver copper concentration as compared with the group fed only a high cholesterol diet. In the aorta
of these animals the copper concentration increases and edema and lipid infiltration are considerably less than in the group
of animals fed only a high lipid diet. |
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| Keywords: | Serum Cu and Zn tissue Cu and Zn concentration copper sulfate experimental atherosclerosis |
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