Kinetics of elemental content changes of bone tissue of mice during evolution under hypokinetic stress |
| |
Authors: | Burkovskaya T E Frontasyeva M V Gundorina S F |
| |
Institution: | 1.Institute of Medical Biological Problems, Moscow, Russia ;2.Frank Laboratory of Neutron Physics Joint Institute for Nuclear Research, Dubna, Russia ; |
| |
Abstract: | Concentration of 13 elements in bone tissue of mice held in tightly spaced cages for 3 wk, which caused an acute stress reaction,
was determined by means of neutron activation analysis. Functionally different bone tissues of mice skeletons—the femur, accomplishing
both supporting and dynamic functions; the parietal bone, being practically immovable; and the ectopic bone, newly formed
under kidney capsule in the place of syngeneic bone marrow implantation—were analyzed. Similar dynamics of the elemental composition
of investigated bones was found: the progressive demineralization owing to the loss of Ca, P, Mg, and Fe is accompanied by
the compensatory inclusion of Sr in the bone tissues. In the ectopic bone, it was not as high. During evolution under hypokinetic
stress, the microelement concentrations (Zn, Cr, Rb, Ru, Br, Co, Sb) change significantly. Results obtained form the evidence
for some system character of osteoporosis at limited mobility. |
| |
Keywords: | Index Entries" target="_blank">Index Entries Bone tissue of mice elemental content hypokinetic stress demineralization bone evolution |
本文献已被 SpringerLink 等数据库收录! |
|