Determination of superoxide dismutase-like activity in some divalent metal saccharinates |
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| Authors: | Maria C Apella Roxana Totaro Enrique J Baran |
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| Institution: | (1) Centro de Referencia para Lactobacilos (CERELA), 4000-S.M. de Tucumán, Argentina;(2) Química Inorgánica (QUINOR), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, C. Correo 962, 1900-La Plata, Argentina |
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| Abstract: | The superoxide-dismutase-like activity of a series of divalent metal saccharinates of general stoichiometry MII(Sac)2(H2O)4]·2H2O (with MII=Mn,Fe,Co,Ni,Cu,Zn) has been investigated using the nitroblue tetrazolium O
2
−
reduction assay. The results show that all these complexes possess the capability to dismutate the superoxide anion generated
in the xanthine/xanthine oxidase system. Interestingly, the greatest activity is shown by the corresponding copper complex.
The results are discussed and compared with those obtained for native superoxide dismutase, which was tested under the same
experimental conditions.
Dedicated to Prof. Pedro J. Aymonino on the occasion of his 65th birthday. |
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| Keywords: | Superoxide dismutase (SOD) SOD mimic metal(II) saccharinates |
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