Effects of micromolar concentrations of manganese, copper, and zinc on α1-adrenoceptor-mediating contraction in rat aorta |
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摘 要: | To determine the influences of the Mn, Cu, and Zn on α1-adrenoceptor (AR)-mediated vasoconstriction, we investigated their effects on vasoconstriction produced by the α1-AR agonist phenylephrine in isolated rings of rat thoracic aorta. The cumulative concentration-contraction curves for phenylephrine
were obtained in the absence and presence of Mn (0.3, 1, 3 μM), Cu (1, 10, 16 μM), and Zn (0.3, 1, 10 μM). Mn, Cu, and Zn each inhibited phenylephrine-mediated contraction in a dose-dependent manner. The maximal phenylephrine-induced
contraction was significantly reduced by the pretreatment of the arterial rings with 10 and 16 μM Cu (p<0.05). The results suggest that variations in the plasma concentrations of metal might lead to changes in α1-AR-mediated constrictive response.
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收稿时间: | 14 December 2000 |
修稿时间: | 28 December 2000 |
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