Effects of statins on oxidative stress |
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Authors: | M Ilker Yilmaz Y Baykal M Kilic A Sonmez F Bulucu A Aydin A Sayal I Hakki Kocar |
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Institution: | (1) Internal Medicine, Etlik-Ankara, Turkey;(2) Pharmaceutical Sciences Departments of Gülhane School of Medicine, Etlik-Ankara, Turkey |
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Abstract: | Free oxygen radicals and insufficient antioxidant enzymes have been implicated in the pathogenesis of hypercholesterolemia
(HC). Trace elements function as cofactors in antioxidant enzymes. Antioxidant system and trace elements were investigated
in many different studies including HC, but these subjects have not been investigated as a whole in these patients. The aim
of the present study was to investigate the antioxidative system and trace elements in hypercholesterolemic patients given
fluvastatin therapy.
We examined malondialdehyde (MDA), copper zinc-superoxide dismutase (CuZn-SOD), and glutathione peroxidase (GSH-Px) activities
together with copper (Cu), iron (Fe), and zinc (Zn) levels in erythrocytes of 35 patients with HC and 27 healthy control subjects.
It was found that in patients with HC, erythrocyte MDA was significantly higher than those of controls and erythrocyte CuZn-SOD
and GSH-Px activities were significantly lower in patients with HC. Erythrocyte iron levels were significantly higher than
those of controls, and erythrocyte copper and zinc levels were significantly lower in patients with HC. Plasma lipid levels
and the oxidative state were analyzed in statin-treatment groups given fluvastatin therapy before and after a 3-mo treatment
period.
In conclusion, we found that fluvastatin has significant antioxidant properties and these effects might be very important
in managing dyslipidemia by improving endothelial function. |
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Keywords: | Zinc iron copper superoxide dismutase malondialdehyde glutathione peroxidase hypercholesterolemia |
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