Simultaneous determination of Zn,Cd, Pb,and Cu in urine of patients with blackfoot disease using anodic stripping voltammetry |
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Authors: | T C Pan C J Horng S R Lin T H Lin C W Huang |
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Institution: | (1) School of Chemistry, Kaohsiung Medical College, 807 Kaohsiung, Taiwan R.O.C.;(2) School of Technology for Medical Sciences, Kaohsiung Medical College, 807 Kaohsiung, Taiwan R.O.C.;(3) Institute of Chemistry, Chung Yuan Christian University, 320 Chung-Li, Taiwan R.O.C. |
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Abstract: | Blackfoot disease (BFD) is an endemic peripheral vascular disorder resulting in gangrene of the lower extremities, especially
the feet, among residents in a limited area on the southwest coast of Taiwan. In the present study, the concentrations of
zinc, cadmium, lead, and copper in urine of BFD patients with matched normal controls are investigated by differential pulse
anodic stripping voltammetry (DPASV) on a hanging mercury drop electrode (HMDE). The analytical results indicate that urinary
copper, cadmium, and lead of the BFD patients are significantly higher than those of the controls. In addition, the patients
showed a significantly lower concentration of zinc in the urine than the normal controls. The possible connection of these
elements with the etiology of the disease is discussed. |
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Keywords: | Blackfoot disease differential pulse anodic stripping voltammetry zinc cadmium lead copper urine specimens |
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