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Effects of Silicon on Osteoblast Activity and Bone Mineralization of MC3T3-E1 Cells |
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| Authors: | Eun-Jin Kim So-Young Bu Mi-Kyung Sung Mi-Kyeong Choi |
| Institution: | 1. State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 214122, China 2. School of Environmental and Civil Engineering, Jiangnan University, Wuxi, 214122, China 3. Department of Engineering Technology, Tongren Polytechnic College, Tongren, 554300, China |
| Abstract: | Previous studies have reported that dietary silicon (Si) intake is positively associated with bone health including bone mineral density. Although the amount of Si intake is high among trace elements in humans, how dietary Si affects bone formation at the cellular level is not well addressed. The purpose of this study was to investigate the role of Si in osteoblast activity and bone mineralization. MC3T3-E1 was cultured as mature osteoblasts and treated with sodium metasilicate (0, 1, 5, 10, 25, 50, and 100 μM) as a source of Si. After 7 days of treatment, 5 and 10 μM of sodium metasilicate significantly increased intracellular alkaline phosphatase activity (p? |
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