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In vitro assessment of the toxicity of metal compounds |
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| Authors: | J Daniel Heck Max Costa |
| Institution: | (1) Division of Toxicology, Department of Pharmacology, University of Texas Medical School at Houston, PO Box 20708, 77025 Houston, Texas |
| Abstract: | A review of in vitro mutagenesis assessment of metal compounds in mammalian and nonmammalian test systems has been compiled. Prokaryotic assays are ineffective or inconsistent in their detection of most metals as mutagens, with the notable exception of hexavalent chromium. Mammalian assay systems appear to be similarly inappropriate for the screening of metal compounds based upon the limited number of studies that have employed those compounds having known carcinogenic activity. Although of limited value as screening tests for the detection of potentially carcinogenic metal compounds, the well-characterized in vitro mutagenesis systems may prove to be of significant value as a means to elucidate mechanisms of metal genotoxicity. |
| Keywords: | Metals mutagenesis by arsenic beryllium cadmium chromium cobalt manganese nickel platinum selenium toxicity of metal compounds mutagenesis of metals in prokaryotes and eukaryotes prokaryotes metal mutagenesis studies in eukaryotes metal mutagenesis studies in |
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