Zinc supplementation attenuates thioacetamide-induced liver injury and hyperglycemia in mice |
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Authors: | Song Yuh-Min Chen Ming-Der |
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Institution: | (1) Department of Medical Laboratories, Taichung Veterans General Hospital, Taichung, Taiwan;(2) General Education Center, Overseas Chinese Institute of Technology, Taichung, Taiwan |
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Abstract: | Zinc supplementation has been shown to improve not only liver dysfunction but also glucose intolerance in subjects with liver
cirrhosis. In this study, we investigated the effects of zinc supplementation on the changes in circulating levels of tumor
necrosis factor-α and total antioxidant capacity in mice with thioacetamide-induced liver injury. The protective effect of
concurrent zinc administration for thioacetamide-induced hepatotoxicity was also examined. The results showed that zinc treatment
significantly attenuated thioacetamide-induced liver injury and hyperglycemia. Furthermore, thioacetamide-induced hepatotoxicity
was markedly weakened by the simultaneous zinc administration. These effects might be attributed to reduced tumor necrosis
factor-α production and elevated total antioxidant capacity induced by the mineral. Our data suggest that zinc supplementation
might be beneficial for the subjects with a high susceptibility to liver injury. |
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Keywords: | Zinc thioacetamide hepatotoxicity glucose intolerance tumor necrosis factor-alpha total antioxidant capacity |
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