1. Department of Internal Diseases, Silesian Medical Academy, ul. Reymonta 8, Katowice, Poland
Abstract:
The effect of an excessive inorganic silicon oral intake on the activity of basic antioxidant enzymes was studied in rats.
Activities of superoxide dismutase, catalase, and glutathione peroxidase were measured in liver and kidney tissues of animals
receiving per os sodium metasilicate nonahydrate (Na2SiO3.9H2O) (Sigma, St. Louis, MO]) dissolved in their drinking water. A decrease of the activity of all the studied enzymes was found
in the samples derived from the experimental group. The results obtained indicate the free oxygen radicals participation in
the potential pathologic events in the conditions of systemic hypersilicemia.