Influence of thyroparathyroidectomy and thyroxine replacement on CU and ZN cellular distribution and on the metallothionein level and induction in rats |
| |
Authors: | G Leblondel A Le Bouil P Allain |
| |
Institution: | (1) Laboratoire de Pharmacologie, Centre Hospitalier Universitaire, 49033 Angers Cedex, France |
| |
Abstract: | Thyroid hormones are involved in copper and zinc distribution in rat tissues. We examined the influence of thyroparathyroidectomy
(TPTY) and of a replacement therapy by T4 on Cu and Zn organ distribution. MT levels were also measured both in basal conditions
and after induction by cadmium. The results confirm that a lack of T4 modified Cu and Zn in serum and tissues. In serum, TPTY
increased Cu (+15%) and ceruloplasmin (+18%), and decreased Zn (−18%). In tissues, Cu was altered in liver (+13%), kidney
(−24%), heart (−16%) duodenum (−18%), and Zn in liver (+25%) and kidney (−10%). The soluble fractions (100,000 g supernatant)
were mainly affected in liver and kidney, and the subcellular fractions in heart and duodenum. MT levels were modified in
basal conditions only in liver (+57%) and kidney (−36%). T4 administration partially prevented the effect of TPTY on both
elements and MT concentrations. Therefore, no evidence is provided for a direct role of T4 in the metabolism of MT in a way
comparable to the effects of glucocorticoids. However, MT could mediate the consequences of TPTY on metal distribution in
certain organs, such as liver and kidney. |
| |
Keywords: | Thyroparathyroidectomy thyroxine copper zinc metallothionein rat |
本文献已被 SpringerLink 等数据库收录! |
|