Mass Spectrometric and Spectroscopic Studies of the Nutritional Supplement Chromium(III) Nicotinate |
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Authors: | Nicholas R Rhodes Tatyana Konovalova Qiaoli Liang Carolyn J Cassady John B Vincent |
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Institution: | (1) Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Tuscaloosa, AL 35487-0336, USA |
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Abstract: | Despite chromium nicotinate’s popular use as a chromium nutritional supplement, the structure and composition of chromium
nicotinate have only been poorly described. As solid chromium nicotinate is intractable, being insoluble or unstable in common
solvents, studies on the solid have been limited, and studies of the solution from which the “compound” precipitates have
additionally provided little additional data. The results of mass spectrometric and spectroscopic investigations designed
to further elucidate the structure and composition of chromium nicotinate are described. The results demonstrated that the
three common methods for producing “chromium nicotinate” all yield different compounds, all of which are polymers of Cr(III),
oxygen-bound nicotinate, hydroxide, and water. Implications for interpreting results of nutritional studies of “chromium nicotinate”
are discussed. |
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Keywords: | Chromium nicotinate Mass spectrometry Electrospray Chromium(III) Nicotinic acid |
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