The effect of exercise and zinc supplement on the hematological parameters in rats |
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Authors: | Alfredo Cordova Francisco José Navas Jesús Fernando Escanero |
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Institution: | (1) Department of Physiology and Biochemistry, University of Valladolid, School of Physioterapy, 42003 Soria, Spain;(2) Department of Biomedicine, University of Zaragoza, Faculty of Medicine, 50009 Zaragoza, Spain |
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Abstract: | This study evaluates the consequences of a session of intensive short-duration exercise and Zn supplementation on different
hematological variables. Forty male Wistar rats were divided into four groups (n=10): the first nonsupplemented, maintained at rest (R); the second nonsupplemented, undergoing exercise (E); the third supplemented
with Zn, kept at rest (ZnR); and the fourth supplemented with Zn, undergoing exercise (ZnE). Zinc supplements (200 ppm) were
given in drinking water. The exercise consisted of a single session of swimming until exhaustion. At rest, RBC, Hb, and Hto
fell (p<0.05), whereas red cell indices, MCV, and MCH rose (p<0.05) in +ZnR compared with R; MCHC remained unchanged (ZnR vs R). After exercise, RBC, Hb, and Hto increased significantly
in E and in ZnE compared with R and ZnR, respectively. In addition, RBC and Hb were lower (p<0.01) in ZnE compared with E; however, MCV and MCH were higher (p<0.05) in the group ZnE vs E. With respect to white blood cells—leukocytes (WBC), limphocytes (LYMPH), and neutrophiles (NEUT)—no
significant differences were observed between groups at rest (ZnR vs R). WBC and LYMPH increased significantly in E with respect
to the rest situation (E vs R), but this did not happen in supplemented animals (ZnE vs ZnR). Level of pH decreased after
exercise both in E and in ZnE, but the fall was lower in the latter. We believe that a single session of swimming until exhaustion
leads to an increase in RBC, Hb, and Hto without causing changes in MCV, MCH, and MCHC. On the other hand, Zn supplementation
leads to an increase of MCV and MCH, although they remain within normal levels. Furthermore, this supplementation produces
lower metabolic acidoses after exercise that leads to leukocyte stability. |
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Keywords: | Zn exercise hematological parameters rats |
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