Trace elements and lipid peroxidation in uremic patients on hemodialysis |
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| Authors: | T H Lin J G Chen J M Liaw J G Juang |
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| Institution: | (1) Graduate Institute of Medicine and School of Technology for Medical Sciences, Kaohsiung Medical College, Kaohsiung, Taiwan, R.O.C.;(2) Department of Nephrology, Tou-Fen Miner's General Hospital, Miaoli |
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| Abstract: | Trace elements and lipid peroxidation in 26 patients with chronic renal failure treated with hemodialysis and 25 healthy subjects
were observed. Both plasma and erythrocyte trace elements and plasma malon dialdehyde (MDA) were examined immediately before
and after hemodialysis. Increased levels of plasma Cu, MDA, and erythrocyte Pb, Mn, Zn, and a significantly decreased plasma
Se, Zn and erythrocyte Se were found in patients before hemodialysis. After a single hemodialysis, erythrocyte Mn, Cu, Zn,
and plasma Cu, Al, and MDA were significantly increased whereas both plasma and erythrocyte Se were lower in patients than
in healthy subjects. The level of MDA was not significantly changed during the single hemodialysis. Both plasma and erythrocyte
Zn levels and plasma Cu and Al were significantly higher after hemodialysis than before hemodialysis. In conclusion, levels
of trace elements are altered by hemodialysis, which may increase patient susceptibility to lipid peroxidation in uremia. |
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| Keywords: | Malondialdehyde trace elements uremic patients hemodialysis lipid peroxidation |
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