The epithelial calcium channels, TRPV5 & TRPV6: from identification towards regulation |
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| Authors: | Els den Dekker Joost G J Hoenderop Bernd Nilius Ren J M Bindels |
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| Institution: | a Department of Cell Physiology, Nijmegen Center for Molecular Life Sciences, University Medical Center Nijmegen, 160 Cell Physiology, P.O. Box 9101, NL-6500 HB, Nijmegen, The Netherlands;b Department of Physiology, Campus Gasthuisberg, KU, Leuven, Belgium |
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| Abstract: | The epithelial calcium channels, TRPV5 and TRPV6, have been extensively studied in epithelial tissues controlling the Ca2+ homeostasis and exhibit a range of distinctive properties that distinguish them from other TRP channels. This review focuses on the tissue distribution, the functional properties, the architecture and the regulation of the expression and activity of the TRPV5 and TRPV6 channel. |
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| Keywords: | ECaC CaT1 Calcium homeostasis Calcium reabsorption Estrogen Vitamin D |
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