| 索曼中毒运动终板乙酰胆碱酯酶活性和接头传递功能的关系 |
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| 引用本文： | 许小珊,沈菊英.索曼中毒运动终板乙酰胆碱酯酶活性和接头传递功能的关系[J].生理学报,1983(1). |
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| 作者姓名： | 许小珊 沈菊英 |
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| 作者单位： | 军事医学科学院药理毒理研究所
(许小珊)，军事医学科学院药理毒理研究所(沈菊英) |
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| 摘 要： | 用大鼠的在体膈肌局部索曼(Soman)中毒法,观察了乙酰胆碱酯酶(ACHE)在运动终板的再生和肌接头传递功能的恢复过程,以及肟类药物(HI-6)对两过程的促进作用。提出终板 AChE 活性与高频间接刺激(100次/秒)引起膈肌强直收缩幅度有一定的关系。中毒早期(30分钟以内)HI-6对索曼抑制的膈肌终板 AChE 有一定的重活化作用,并能相应地恢复肌接头的传递功能。
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| 关 键 词： | 大鼠膈肌 索曼中毒 HI-6 运动终板 乙酰胆碱酯酶活性 肌接头传递 |
THE RELATIONSHIP BETWEEN ACETYLCHOLINESTERASE ACTIVITY AT MOTOR END-PLATES AND NEURO-MUSCU-LAR TRANSMISSION AFTER SOMAN INTOXICATION |
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| XU XIAO-SHAN AND SHEN JU-YING.THE RELATIONSHIP BETWEEN ACETYLCHOLINESTERASE ACTIVITY AT MOTOR END-PLATES AND NEURO-MUSCU-LAR TRANSMISSION AFTER SOMAN INTOXICATION[J].Acta Physiologica Sinica,1983(1). |
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| Authors: | XU XIAO-SHAN AND SHEN JU-YING |
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| Abstract: | By using local intoxication of soman(pinacolyl methylphospho-nofluoridate)the processes of regeneration of AChE activity at motor end-plates and of recoveryof neuro-muscular transmission of rat diaphragm were observed.An ameliora-tive effect of HI-6 on these processes was also observed.It was found that theAChE activity at motor end-plates was somewhat related to the strength of tetaniccontraction of the diaphragm induced by high-frequency indirect stimulation(100/s).The AChE activity inhibited by early intoxication of soman at themotor end-plates could be reactivated by HI-6(within 30 min),together with arecovery of neuro-muscular transmission. |
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| Keywords: | rat diaphragm soman intoxication HI-6 motor end-plates AChE neuromuscular transmission |
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