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正常大鼠植入高血压大鼠肾脏后动脉血压的变化
作者姓名:Li XB  Wang Z  Liu BC  Zhu YC  Yao T
作者单位:1. 上海医科大学生理学教研室,医学神经生物学国家重点实验室,上海,200032
2. 上海医科大学华山医院泌尿科,上海,200040
基金项目:国家教委博士点基金 !(No 1332 10 4),美国纽约中华医学基金会基金 !(No 90 52 7)资助项目
摘    要:本实验对12周龄的自发性高血压大鼠(spontaneouslyhypertensiverat,SHR)及其对照组WistarKyoto(WKY)大鼠进行了肾脏移植的研究,并观察受肾移植大鼠动脉血压的变化以及免疫抑制剂对动脉血压的影响。用尾套法对接受同窝另一同胞WKY大鼠肾脏移植且存活5周的6只WKY大鼠(A组)及接受SHR肾脏移植且存活5周的6只WKY大鼠(B组)的尾动脉收缩压进行检测,移植前A、B两组受肾移植大鼠的尾动脉收缩压分别为180±093和183±068kPa,无统计学显著差异(P>005);移植后3、4、5周时,B组大鼠的尾动脉收缩压显著高于A组大鼠,移植后5周时,A,B两组大鼠的收缩压分别为190±071和230±069kPa(P<0001);所用剂量的免疫抑制剂CsA对双侧肾脏完整以及右侧肾脏切除的SHR、WKY大鼠的动脉血压无显著影响。以上结果表明,SHR的肾脏在高血压的形成中可能起重要作用

关 键 词:肾脏移植  动脉收缩压  SHR  高血压

Changes in blood pressure in normal rats transplanted with kidney of SHR
Li XB,Wang Z,Liu BC,Zhu YC,Yao T.Changes in blood pressure in normal rats transplanted with kidney of SHR[J].Acta Physiologica Sinica,1999,0(6):630-636.
Authors:Li X B  Wang Z  Liu B C  Zhu Y C  Yao T
Institution:Department of Physiology and State Key Laboratory of Neurobiology, Shanghai Medical University, Shanghai 200032.
Abstract:The experiments were performed on spontaneously hypertensive rats (SHR) and Wistar Kyoto(WKY) rats of 12 weeks old. Systolic blood pressure in WKY recipients receiving an SHR or WKY rat kidney was observed and the influence of immuoinhibitor cyclosporin (CsA) on blood pressure was investigated. The systolic blood pressure (SBP) of tail artery was measured by tail cuff technique in 6 WKY recipients of one SHR kidney and 6 WKY recipients of a WKY kidney from before transplantation to 5 weeks after transplantation. At the time when kidneys were harvested for transplantation from 12 week old SHR and WKY rats, the SBP in WKY recipients was not significantly different. The SBP in WKY recipients of an SHR kidney was significantly higher than that in WKY recipients of a WKY kidney at 3, 4 and 5 weeks after transplantation. The immunoinhibitor CsA exerted no effect on the arterial blood pressure in either intact or uninephrectomized SHR and WKY rats. The results indicate that the kidney of SHR plays an important role in the pathogenesis of genetic hypertension.
Keywords:spontaneously hypertensive rat  kidney cross  transplantation  blood pressure
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