脊髓高位横断诱发大鼠急性胃溃疡机制的研究

在颈七水平横断大鼠脊髓以诱发急性胃溃疡。结果表明:(1)脊髓横断动物的体温随环境温度而下降,体温的下降可能是诱发溃疡的重要原因之一;(2)注射肾上腺素可减轻溃疡和防止体温下降,且两者均呈剂-效关系;(3)切除肾上腺可使脊髓横断诱发的溃疡明显减轻,如补充注射地塞米松则可使之重新加重,但体温的下降在以上情况下均不受影响;(4)脊髓横断后胃粘膜泌酸和内分泌功能的改变可能与溃疡生成有关。

STUDIES ON THE MECHANISM OF ACUTE GASTRIC ULCERATION INDUCED BY HIGH SPINAL CORD TRANSECTION

Spinal cord of the rat was transected at C_7 level to produce acute gastric ulcer.It was observed as follows:(1)The body temperature(B.T.)of the cord transectedanimals fell in a good agreement with ambient temperature.It appears thatthe fall in B.T.is one of the main causes inducing ulceration.(2)Administrationof epinephine decreased ulceration and prevented the fall in B.T.both in a dose-dependent manner.(3)Cord transection induced ulcer formation was markedlyattenuated by adrenalectomy and exacerbated again by displacement with dex-amethason,but the fall in B.T.was unaffected at all in either case.(4)The var-iations in acid secretory and endocrine function of gastric mucosa after transectionmight be involved in ulcer formation.