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猫听觉脑干诱发电反应中P_(2a)和P_(2b)波的起源
引用本文:康健,魏保龄.猫听觉脑干诱发电反应中P_(2a)和P_(2b)波的起源[J].生理学报,1986,38(3):259-265.
作者姓名:康健  魏保龄
作者单位:中国医科大学听力研究室 (康健),中国医科大学听力研究室(魏保龄)
摘    要:在33例猫将普鲁卡因或海人酸微量注入耳蜗核(CN)和上橄榄复合体(SOC)内,观察ABR的相应改变,以分析P_(2a)和P_(2b)波的来源。猫P_(2a)波的出现率与电极导联有关,颅顶-颈后为90%,颅顶-乳突仅为18%。普普卡因注入CN后,同侧耳短声诱发的ABR仅保留P_1波,对侧耳的则无改变。海人酸注入CN后,P_1和P_(2a)存留,P_(2a)不减小反而增大。普鲁卡因注入双侧SOC,可使P_3、P_4和P_5消失。这些结果提示,P_(2a)波主要起源于CN区域内的第一级听觉传入神经元轴突并受第二级神经元负电位的影响,P_(2b)波主要起源于SOC以下的第二级听觉传入神经元,猫的P_(2a)和P_(2a)波与对侧脑干结构无关。

关 键 词:听觉脑干诱发电反应  电位起源  普鲁卡因效应  海人酸效应

ORIGINS OF P_(2a) AND P_(2b) OF AUDITORY BRAINSTEM RESPONSES IN THE CAT
KANG JIAN,WEI BAO-LING Audiological Laboratory of China Medical University.ORIGINS OF P_(2a) AND P_(2b) OF AUDITORY BRAINSTEM RESPONSES IN THE CAT[J].Acta Physiologica Sinica,1986,38(3):259-265.
Authors:KANG JIAN  WEI BAO-LING Audiological Laboratory of China Medical University
Institution:KANG JIAN;WEI BAO-LING Audiological Laboratory of China Medical University
Abstract:Procaine or kainic acid was microinjected into the cochlear nucleus (CN) andsuperior olivary complexus (SOC) in 33 cats. Origins of P_(2a) and P_(2b) were inve-stigated through observing effects of these agents on auditory brainstem responses(ABR). Incidence of the appearance of P_(2a) in cats was related to site of the refer-ence electrode. It was 90% in vertex-vs-neck lead, but only 18% in vertex-vs-mastoid lead. After injection of procaine into CN, only P_1 remained in the ipsi-lateral ABR while the contralateral ABR did not change. After injection of kainicacid into CN, both P_1 and P_(2a) remained but the amplitude of P_(2a) is increased.P_3, P_4 and P_5 disappeared after bilateral injection of procaine into SOC. Theseresults suggest that P_(2a) is generated mainly from the axon terminals of the primaryauditory afferent neurons in the vicinity of CN, and is somewhat modified by anegative potential generated from the second auditory afferent neurons below SOC.Contralateral brainstem structures have no contribution to P_(2a) and P_(2b) in the cat.
Keywords:auditory brainstem response  origin of potential  procaine effect  kainic acid effect
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