| 肾上腺髓质素的降压作用及其在组织中分布的观察 |
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| 引用本文： | 宋良文,马宪梅,魏英杰,汤健,张秉钧,王泰龄.肾上腺髓质素的降压作用及其在组织中分布的观察[J].生理学报,1995(4). |
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| 作者姓名： | 宋良文 马宪梅 魏英杰 汤健 张秉钧 王泰龄 |
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| 作者单位： | 北京医科大学心血管研究所，北京中日友好医院病理科，延边医学院分院药理教研室 |
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| 摘 要： | 本实验用电生理和免疫组化方法观察了肾上腺髓质素（ａｄｒｅｎｏｍｅｄｕｌｌｉｎ，ＡＭ）对正常和高血压大鼠血压的影响和对主动脉环张力的作用以及ＡＭ在一些组织中的分布特点。结果显示ＡＭ对高血压大鼠的降压幅度远大于正常鼠；对主动脉环张力的降低作用具有剂量依赖性和内皮依赖性；ＡＭ免疫组化反应除在嗜铬细胞瘤和肾上腺髓质细胞内呈阳性反应外，在肺、肾和心肌组织内都显示出不同程度的阳性。提示ＡＭ在机体血压和循环调节中具有重要作用。
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| 关 键 词： | 肾上腺髓质素，嗜铬细胞瘤，肾上腺髓质，高血压 |
OBSERVATION ON HYPOTENSIVE ACTIOX OF ADRENOMEDULLIN AND ITS DISTRIBUTION IN TISSUES |
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| SONG LIANG-WEN, MA XIAN-MEI,WEI YING-JIE AND TANG JIAN.OBSERVATION ON HYPOTENSIVE ACTIOX OF ADRENOMEDULLIN AND ITS DISTRIBUTION IN TISSUES[J].Acta Physiologica Sinica,1995(4). |
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| Authors: | SONG LIANG-WEN MA XIAN-MEI WEI YING-JIE AND TANG JIAN |
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| Abstract: | The effect of adrenomedullin (AM) on blood presure and tension of aortic rings were studied in normal and in either spontaneous or renal hypertensive rats(SHR/RHR). The distribution characteristics of AM in viscera was also investigated. It was found that the hypotensive action of AM was far more prominent in hypertensive than in normotensive rats. The tension lowering action on the aortic rings is dose dependent and requires the presence of endothelium. lmmunohistochemistry reactivity of AM of different degrees were also found in lung, kidney and myocardium, in addition to cells of pheochromocytoma and ndrenomedulla. It was suggested that AM may play an important role in the regulation of blood presure and visceral blood circulation. |
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| Keywords: | adrenomedullin pheochromocytoma adrenomedulla hypertension |
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