胃壁肾上腺素能受体作用的分析

选用46只 Wistar 大鼠,分别观察了酚妥拉明和心得安对迷走神经完整和切断迷走神经大鼠胃内压的影响。结果为:酚妥拉明对迷走神经完整大鼠的胃内压没有影响,但能使切断迷走神经大鼠的胃内压明显下降,心得安可使去迷走神经和迷走神经完整大鼠的胃内压均升高,且两者无明显差异。结果表明:(1)支配胃的肾上腺素能神经紧张性作用主要表现为抑制;(2)β-受体可能仅位于胃平滑肌上,且介导抑制作用;(3)依赖迷走神经发挥作用的 α-受体介导抑制作用,而胃壁平滑肌上的 α 受体介导兴奋作用。

AN INVESTIGATION ON ADRENERGIC RECEPTORS IN RAT STOMACH

The effects of phentolamine and propranolol on intragastric pressure were observed in 46 Wistar rats. The results showed that: (1) phentolamine did not cause significant changes in the intragastric pressure of intact rats, but, it could obviously decrease the intragastric pressure of rats with vagotomy. (2) propranolol increased the intragastric pressure of intact rats or rats with vagotomy. We concluded that (1) tonic action of adrenergic nerves in stomach is mainly inhibitory; (2) beta-adrenoceptors, which may be present on the smooth muscle of stomach mediate sympathetic inhibition; (3) alpha-adrenoceptors, which come into play through vagus, mediate inhibition, but alpha-adrenoceptors, which may be present on the smooth muscle, mediate sympathetic excitation.